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Seventy patients(22%)had infarction/ischemia and/or atrophy.Infarction/ ischemia was noted in 39 children(13%)who had no history of a stroke(the" silent"group).The prevalence rates for silent lesions were 27%for sickle- cell anemia and 3%for hemoglobin sickle-cell disease.For patients with sickle-cell anemia and a history of cerebrovascular accident,infarction/ ischemia lesions typically involved both cortex and deep white matter, while silent lesions usually were confined to deep white matter.Within the age range studied,the prevalence of infarction/ischemia did not increase significantly with age,although older patients with lesions had more lesions than did younger patients with lesions.Brain MR imaging showed infarction/ischemia in the absence of a recognized cerebrovascular accident in 13%of patients.The prevalence of these lesions did not increase significantly between the ages of 6 and 14 years,suggesting that lesions are present by age 6.However,the increase in the average number of lesions per patient with age may indicate progressive brain injury. |
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asymptomatic
cerebral cortical atrophy
cerebral infarction
cerebrovascular accident
cerebrovascular accident,infancy and childhood
cerebrovascular accident,silent
hemoglobin abnormality,neurologic complications of
intracerebral hemorrhage
MRI
MRI,abnormal
sickle cell disease
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